Amyloid transthyretin cardiomyopathy (ATTR-CM) is a progressive and life-threatening heart disease that can lead to increased ventricular wall thickness, restrictive cardiomyopathy, and heart failure.

Although primary intraosseous Rosai-Dorfman disease (RDD) may be characterized by fibrosis and an increase in Ig4+ plasma concentration, it does not meet the diagnostic criteria for immunoglobulin ...

A CRISPR/Cas9-modified Janus kinase 2 (JAK2) V617F model may be useful to develop new therapies against myeloproliferative neoplasms (MPNs), showed a new study published in the International Journal ...

Individuals with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) undergoing treatment with fludarabine, cyclophosphamide, and rituximab (FCR) are at increased risk for other ...

Gastrointestinal (GI) symptoms are the second most frequent clinical manifestation of systemic mastocytosis (SM), after itching. They affect 15% to 85% of patients and have a significant impact on ...

A new study has found that a novel functional C1-INH (fC1-INH) dried blood spot (fC1-INH DBS) assay for hereditary angioedema (HAE) has similar sensitivity and specificity as conventional testing and ...

Adherence to existing emergency department (ED) guidelines on the time to first analgesic administration (TFAA) in patients with sickle cell disease (SCD) is low and appropriate care is often delayed, ...

Performing autologous stem cell transplantation (ASCT) in patients with cold agglutinin disease (CAD) presents significant challenges but can be achieved safely with rigorous thermal control and a ...

Which of the statements below about the complications of immunoglobulin G4-related disease (IgG4-RD) are correct? Select one of the options for each question, then submit your answers to see how well ...

Patients with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) who were treated with tafamidis for a year showed stabilization of several cardiac biomarkers, according to a study published in ...

Sickle cell disease (SCD) is caused by mutations in the HBB gene, 1 which encodes for the beta chain of the adult hemoglobin protein (HbA). The mutated gene produces a defective beta-globin chain ...

There is significant variability in terms of management practices across Canadian medical centers in terms of red blood cell (RBC) and platelet transfusions in preterm newborns, according to a study ...