Granted, you could just wire the power supply to be on all the time, but it is nice to be able to turn everything off. The plan was to use the always-on 5V standby rail to drive a pair of relays.

Your board will automatically receive a regulated 5V supply and power up straight ... making it one of the safest ways to ...

Now, he reports that, so far, those boards have been running long-term without problems. Together with [Eben]’s comment, this instills confidence in us when it comes to our RP2040 forays and 5V ...