Xeroderma pigmentosum (XP) is a rare genetic disease that affects young children. These young patients, called children of ...

In the first stage, the NER protein XPC (xeroderma pigmentosum group C) acts like a first responder that locates the site of the damaged DNA, or lesion, and then twists the DNA helix to make the ...

Five of the conditions (xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy, Down syndrome, and triple-A syndrome) display a defect in the nucleotide excision repair pathway ...

These disorders include ataxia-telangiectasia (AT), a degenerative motor condition caused by failure to repair oxidative damage in the cerebellum, and xeroderma pigmentosum (XP), a condition ...

At risk individuals include: Transplant recipients (solid organ and stem cell) Genetic syndrome patients (Gorlin's, Rombo, Bazex, xeroderma pigmentosum, Muir-Torre) Lymphoma patients (non-Hodgkin ...

The native structure of genomic DNA can be damaged in many ways, both by external agents and from within the cell as a consequence of normal metabolism In an effort to maintain their genomic ...