Figure 2. Summary of role of cholesterol and hypercholesterolemia in hypertension and atherosclerosis. HMG-CoA reductase inhibitors (statins) exert both direct and indirect (cholesterol-lowering) ...

Despite certain structural similarities, some physicochemical profiles (notably lipophilicity) vary markedly between statins (Figure 1). The ability of statins to inhibit HMG-CoA reductase is ...

Alternative statin dosing schedules using once-, twice- or three-times a week, or every-other-day dosing, have been investigated as methods to reduce myalgias and achieve efficacy in lowering LDL ...