All diseases exist on a continuum, and the damage often begins early—sometimes as soon as a child is weaned off breast milk ...

Conventional photosensitizers (PSs) used in photodynamic therapy (PDT) have shown preliminary success; however, they are often associated with several limitations including potential dark toxicity in ...

Cigarette smoking is the leading cause of preventable death worldwide. It causes chronic lung disease and predisposes individuals to acute lung injury and pulmonary infection. Alveolar macrophages are ...

Hillestad V, Espe EK, Cero F, Larsen KO, Sjaastad I, Nygård S, Skjønsberg OH, Christensen G. IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice. Acta ...

Obstructive sleep apnoea (OSA) is recognised to be a potent risk factor for hypertension, coronary heart disease, strokes and heart failure with a reduced ejection fraction. However, the association ...

Hypoxia-Responsive Stereocomplex Polymeric Micelles with Improved Drug Loading Inhibit Breast Cancer Metastasis in an Orthotopic Murine Model. Min Lu. Min Lu. Institute of Special Environmental ...

It is well established that exposure to rodents to chronic alveolar hypoxia (usually 3 weeks) primarily causes constriction of resistant vessels in the pulmonary vascular bed. When hypoxia is ...

Alveolar macrophages (AMs) are indispensable to prevent pulmonary alveolar proteinosis and clear inhaled pathogens. Receptor for activated C kinase 1 (RACK1) is a versatile adaptor protein that ...

Definitions of hypoxaemia, hypoxia, type 1 respiratory failure and hyperoxaemia. Definition of hypercapnia and type 2 respiratory failure. ... Alveolar carbon dioxide tension PO 2 Oxygen tension ...

Typically, these changes include damage or enlargement to the alveoli, which is characteristic of emphysema. CT scans play an important role in the diagnosis and evaluation of emphysema.

Our study identifies hypoxia-driven histone lactylation as a potential target to block immunosuppressive neutrophils and boost the effects of immunotherapy in glioblastoma and in other cancer settings ...